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Research Manuscripts

Identifying Drivers of Neuropathic Pain in Arthritis

September 7, 2022 12 min read
ABSTRACT Rheumatoid arthritis (RA) is a debilitating autoimmune disease that causes painful inflammation within joint tissue. Despite the success of modern therapeutics in treating detectable inflammation, patients with RA often experience lingering neuropathic pain. Neuropathic... Read More

The Effect of the Amino-Terminal Fragment (ATF) on the Activity and Inhibition of Urokinase-Type Plasminogen Activator (uPA)

September 2, 2022 20 min read
ABSTRACT Urokinase-type plasminogen activator (uPA) is a serine protease responsible for cleaving and activating inactive plasminogen to its active form, plasmin, which is involved in fibrinolysis, angiogenesis, and extracellular matrix degradation. Plasmin, in turn, is... Read More

Meta-Analysis of the Pacific Oyster Microbiome: Characterizing Microbiome-Environment Associations and Core Tissue Microbiomes

August 29, 2022 24 min read
INTRODUCTION Oysters are an integral part of many marine ecosystems. They provide food for several species of snails and crabs and act as natural water filters, preventing algal blooms and nutrient-induced oxygen depletion in aquatic... Read More

Incorporation of Non-Canonical Amino Acids in Vivo Via the Quadruplet Codon System

August 22, 2022 19 min read
The structure and function of proteins in the human body is largely limited by the number of amino acids that are naturally generated by the genetic code. Out of 64 codons, 61 of them code... Read More

The Path of Most Resistance: Molecule Equisetin Found in Marine Sponges is a Possible Breakthrough Against Multi Drug-Resistant Bacteria

August 15, 2022 9 min read
Antibiotics are crucial in protecting humans from a large range of bacterial diseases. Scientists have created several types of antibiotics that are now prescribed regularly to treat many infections. Unfortunately, the misapplication of antibiotics for... Read More

WxxxE Signature Motif Containing Bacterial Effectors Interact with the Host Engulfment Pathway to Control Pathogenesis

August 16, 2021 7 min read
INTRODUCTION Despite many prevention efforts, foodborne illnesses remain a serious global health threat.¹ The Centers for Disease Control and Prevention (CDC) recently reported that approximately 48 million people in the United States become ill with... Read More

The Importance of Protein-Protein Interactions in Drug Discovery and Inhibition of Mycolic Acid Production in Myobacterium Tuberculosis

August 16, 2021 6 min read
INTRODUCTION Tuberculosis (TB), a disease which primarily targets the lungs, is caused by the human pathogen Mycobacterium tuberculosis (Mtb). TB spreads when an infected person coughs, sneezes, or speaks, passing the bacteria onto someone else.... Read More

Small Molecule Extracellular Electron Shuttles: Mechanism of Electron Transfer and Biotechnological Applications

August 16, 2021 8 min read
EXTRACELLULAR ELECTRON TRANSFER AND MICROBIAL NATURAL PRODUCTS Oxygen is an essential part of the electron transport chain, functioning as the terminal electron acceptor in aerobic respiration.¹ Without oxygen, an aerobic cell is unable to complete... Read More

Novel Non-SSRI Treatments for OCD: Pharmacotherapies Targeting CSTC Signaling

July 30, 2021 8 min read
INTRODUCTION Obsessive-Compulsive Disorder (OCD) is a psychiatric illness characterized by intrusive thoughts, designated as obsessions, and repetitive compulsions, such as motor-related fixations.¹ Symptoms of OCD include checking behavior–compulsive interactions with switches or locks–and fixation on... Read More

About SQ Online

SQ Online is part of the Saltman Quarterly program, a biology student organization committed to communicating science and research. The late Dr. Paul Saltman inspired the program’s creation, and the Saltman Family continues to generously support our efforts. For more on Dr. Saltman’s legacy, read our tributes.

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